I have hit a rough patch as of late and have tried numerous BP medications Depakote, Lithium, Seroquel, Zyprexa, etc, etc and have had adverse reactions to all of them. And by rough, I mean I have been off of work for three weeks.
This is my last resort; my shrink and I are going to have to medicate the h-ll out of me to get back to work. Read More I have rapid cycling bipolar as well as post traumatic stress disorder.
He has me on Xanax for anxiety, Zoloft and Neurontin for mood stabilizer. Can anyone tell me what they think of Neurontin and if it words? I am very intrigued to know if I am on a good medicine or if this isn't good. I don't go back to him for 3 weeks. They worked well for me for a long time, but my moods progressively started to swing worse and worse through the years.
Either I was BP the whole time, or the my mental illness progressed into it. Medication is a Catch for me; I am very sensitive to them. I either respond well to them or they cause severe adverse side effects. Read More Same situation as Abilify.
Too expensive and I am tired of being gutted by the APs. I guess I am just venting, but I don't know what to do. We have the same friggin discssion about these meds every time I see her. I am starting to feel like a difficult patient, but I feel like I have to put my foot down..
The biggest reason why I was laid up and lost one of my jobs was because everything we tried messed me up. Read More Well, I don't really have a great deal of depression when dealing with the Neurontin. In my experience I found it gentler than the normal seroquel. March 11, , pm 3 I was on Seroquel before I started Abilify, and I can say that by itself, it definitely helped me manage anxiety and psychosis. I used to sleep a lot and I could sit still on the couch for hours. Drugs like amitriptyline and chlorpromazine can help with pain as well as mental illness.
I have never tried pregablin, but it can also help with pain and anxiety. The same kind of interaction is observed in the case of taking Quetiapine and valium together. Benzodiazepines are drugs not to take with Seroquel. They work by affecting brain chemistry and help to regulate mood. Cymbalta and Seroquel, when taken together, complement each other well with mild interactions. The sleepiness and drowsiness may increase slightly, but not to that extent, which can become dangerous.
However, in some cases, this medication and Cymbalta may cause serious interactions. When this drug and Effexor are taken together, they can increase the risk of an irregular heart rhythm that can be quite serious. Although it is a rare side effect, the possibility of such an interaction is present.
Interactions With Antipsychotics Quetiapine itself belongs to the antipsychotic drug class. Sometimes, patients might combine this medication with other antipsychotic drugs to enhance antidepressant effects. Certain antipsychotic drugs can safely be combined with Quetiapine for the treatment of various mental disorders.
According to this research about the combination of Abilify and Seroquel for treating patients of schizophrenia, the results concluded that the combination was well-tolerated and generally safe.
Taking Zyprexa and this drug together can result in a slight worsening of the side effects, including weight gain. A doctor may prescribe these two medications together if he believes that the patient will benefit from this combination as compared to taking any of them alone.
However, losing weight on Seroquel and a combination with another antipsychotic substance can become a challenging task. SSRIs work by increasing the levels of serotonin a neurotransmitter in the brain. Through recent studies and research, it is shown that combining Quetiapine with SSRIs can prove to be beneficial in treating mental conditions such as depression and schizophrenia.
An extensive study was carried out to determine the safety and efficacy of using Quetiapine with SSRIs on patients with major depressive disorders. This study concluded that Quetiapine and SSRIs are well-tolerated, and no significant drug interactions were found. However, when Seroquel and Lexapro are used together, there is the chance of a very rare side effect occurring, which is cardiac arrhythmias. This is when the heart rhythm is irregular, and it beats abnormally, which can be potentially life-threatening.
That is why before Seroquel and Lexapro are used together, a doctor should be aware. It occurs more commonly in those with previous cardiac conditions. The same applies to Zoloft and Seroquel. Other Seroquel Interactions Quetiapine drug interactions can appear with certain other drugs as well. Some of these interactions may be mild and can be well-tolerated if Quetiapine and the doses of other medications are taken as prescribed by the doctor.
However, in some cases, drug interactions of this medication with other medicines may have severe effects on health, which should be avoided entirely. Combining Lamictal and this drug for the treatment of these disorders has shown to improve the treatment success and are both well-tolerated together. Ambien belongs to the class of drugs called sedatives that are used to treat sleep problems and insomnia.
Taking Ambien and this drug together does not cause any significant interactions and is well tolerated.
Lyrica is a drug which slows down nerve impulses; this watch might be very dangerous if one attends to work requiring alertness while taking the drug because the person might feel sleepy and drowsy.
Toth organized a study to assess the effect of substituting gabapentin with pregabalin patients with peripheral neuropathy-related neuropathic pain.
French et al. I have peripheral neuropathy. Http://www.catchpenny.org/thoth/tree/hsv-prophylaxis-valtrex-gram.html drugs can cause some of the same side effects, as well as some different ones.
Because of this, some states are electing to change gabapentin to a controlled substance, like Lyrica. Because standard pregabalin capsules are available in a greater number of dosing increments 8 total relative to standard gabapentin capsules and tablets combined 5 totalsome might perceive pregabalin as favorable over gabapentin in page aspect of dosing.
That said, because there are serious limitations elavil with this study, we cannot be confident that the results suggesting compare pregabalin is more effective than gabapentin in postherpetic neuralgia are accurate or clinically-relevant. Lyrica neurontin, Pfizer, has received FDA approval for an extended and version of Lyrica that will allow for once daily administration.
Lyrica is a drug which slows down nerve impulses; this feature might be very dangerous if one attends to work requiring alertness while taking the drug because the person might feel sleepy and drowsy. Several side effects are associated with the use of Lyrica. In the serious cases, people experience blurred vision, muscle pain and weakness, easy bleeding, limb swelling and weight gain.
Some may experience drowsiness, breast swelling, constipation, difficulty in concentration etc. Some drugs, if taken simultaneously, have the potential to weaken its effect or create complications. Such drugs are allergy medicine, sedatives, depression medicine, sleeping tablets, blood pressure medicine etc.
Gabapentin Gabapentin also known by trade names Horizant or Neurontin is also a commonly prescribed antiepileptic anticonvulsant drug. While it is prescribed for epilepsy and seizures, it is also used for the post herpetic neuralgia and Restless Legs Syndrome. The other solution was to try Cymbalta. Helpful - 0 uk2 Hi I was on lyrica for year and an half from 75mg to mg. I have fibromyalgia and took it for that but i put two stone on with it and since i've been off it lost a stone and a half since then in 6 mths, at its lower dose it makes you tired the higher the dose the more i found it kept me awke and fight my fatiuge, it helped with my muscle spsams and nerve pain but i had the worst time ever coming off it it took me 6 mths to come off it as before i tried to come off it in a month and ended up having an awfull experience but i was tring out a parkinson drug at the time which i had to come off as well.
I'm now on requip and fentanal patches and clonazapam and find that works better then the lyrica for me, i also got aggressive and agitated on the higher dose, i find its a drug that works well at a low dose but as you are on long term your body gets used to that and you go up and thats when the side effects like weight gain and aninxty, but the weight gain was the worst for me, i feel more foggy off it and less with it but then i've been dx with meniere's disease and suffering from vertigo so that could be combined to that.
Im glad the lyrica is working for you. Data from all trials were evaluated with an indirect comparison approach wherein the placebo served as a common comparator. Researchers performed a base-case analysis using intention-to-treat last observation carried forward method and two sensitivity analyses among completer and responder populations.
Although sensitivity analyses substantiated the findings of the base-case analysis, the sensitivity analyses did not find statistical significance between pregabalin and gabapentin. Still, there are some serious limitations associated with this study including: 1 efficacy estimates were based on indirect comparisons; 2 data were extracted from trials with different characteristics duration, sample specifics, dosing regimens, concurrent substance use, etc.
In summary, this study suggests that pregabalin could be more effective than gabapentin as an adjunct treatment in refractory partial epilepsy. The meta-analysis conducted by Delahoy et al. Additionally, the meta-analysis was full of limitations including: 1 indirect comparisons of pregabalin and gabapentin; 2 unequal potency-of-dose comparisons; 3 funding by Pfizer Inc. Even if the meta-analysis by Delahoy et al. The most reliable data regarding the respective efficacies of pregabalin and gabapentin in the treatment of partial onset seizures were derived from a study by French et al.
Results of the study indicated that pregabalin and gabapentin treatment yield similar reductions in day seizure rates This study provided Class II evidence to suggest that pregabalin and gabapentin do not differ in efficacy as adjuncts for the treatment of partial onset seizures. What about efficacy for other medical conditions? Pregabalin vs. Gabapentin In the U. Though gabapentin Neurontin is not authorized by the FDA to treat neuropathic pain or fibromyalgia, it is regularly prescribed as an off-label intervention for these conditions.
Neuropathic pain Evaluation of efficacy and safety of gabapentin, duloxetine, and pregabalin in patients with painful diabetic peripheral neuropathy. Devi et al. For the study, patients with a history of DPNP-related pain minimum mm score on visual analogue scale VAS were assigned at random to receive gabapentin, pregabalin, or duloxetine for a week duration. The primary endpoint was DPNP-related pain score on an point visual analogue scale VAS , and secondary endpoints included: sleep interference scores, patient global impression of change, and clinical global impression of change.
Of the participants: 50 received gabapentin; 52 received pregabalin; and 50 received duloxetine. Results indicated that all 3 treatments gabapentin, pregabalin, duloxetine significantly: 1 reduced point visual analogue pain scale VAS scores; 2 decreased sleep interference; and 3 improved patient and clinical global impressions of change.
While there were trends for greater pain reduction, superior sleep improvement, and faster onset of therapeutic action with pregabalin relative to gabapentin and duloxetine , there were no statistically-significant differences in outcomes between groups to suggest that one treatment was more or less effective than the others.
Researchers concluded that monotherapy with gabapentin, pregabalin, and duloxetine provide significant pain relief among patients with DPNP. The findings of this study indicate that pregabalin and gabapentin do not differ in efficacy for the management of neuropathic pain. Toth organized a study to assess the effect of substituting gabapentin with pregabalin patients with peripheral neuropathy-related neuropathic pain.
It was concluded that pregabalin may provide additional pain relief relative to gabapentin in the treatment of neuropathic pain. Despite the suggestion by authors of this study that pregabalin may be more efficacious than gabapentin in the treatment of neuropathic pain, there are major limitations to consider.
Limitations associated with this study include: 1 no transition from pregabalin to gabapentin only from gabapentin to pregabalin ; 2 uneven treatment periods short-term gabapentin use prior to transition but long-term pregabalin use ; 3 unblinded status of patient assessments; 4 no control group; 5 small sample size; 6 possible placebo-like effect upon transition to pregabalin ; 7 author received support from Pfizer Inc.
Quilici et al. More specifically, researchers extracted data from high-quality, randomized, placebo-controlled trials to compare the respective magnitudes of therapeutic efficacy relative to a placebo — associated with each intervention. It was reported that 3 studies with duloxetine; 6 with pregabalin; 2 with gabapentin; and zero with amitriptyline met inclusion criteria for the meta-analysis.
Using random-effects and fixed-effects analyses, researchers stated that gabapentin, pregabalin, and duloxetine were all more effective than a placebo in the treatment of diabetic peripheral neuropathic pain. Researchers concluded that gabapentin, pregabalin, and duloxetine are of comparable efficacy in the treatment of diabetic peripheral neuropathic pain. This study supports the idea that gabapentin and pregabalin are equally efficacious in the management of diabetic neuropathic pain.
In a meta-analysis by Quilici et al. In the small-scale study by Toth , it appeared as though pregabalin might be more efficacious than gabapentin in the treatment of neuropathic pain, however, Toth acknowledged that the study was full of notable limitations unequal comparison, no blinding of patient assessments, small sample, support from Pfizer, etc. The most useful data for comparing the head-to-head efficacies of pregabalin and gabapentin in the treatment of neuropathic pain were derived from a study by Devi et al.
The study by Devi et al.
Recently my Doctor added cymbalta for nerve pain. Does any have neurontin similar pain? And do elavil natural therapy than I do pharmaceutical. You won't feel it kick in or really wear off, so it's more like a and benzo for compare with a half life of hours.
Read More Cymbalta actually neurontin for me after I had a major back interaction You should get better responses if you do that. He is lucky to have your caring, concern and compassion. It seroquel also approved for use in diabetic neuropathy which can be severe and is often of a burning nature.
It is often used in neuralgia.
My symptoms are feelings similar to what you'd feel when someone scratches their compare down a neurontin. The minimal and isn't worth the amont of drowsiness elevill caused in the day elavil. Can I neurontin your thoughts about 40mg vs. I won't know for some time if I'm using the placebo and the actual Cymbalta.
See web Abstract In this single center, double blind and randomized trial gabapentin as a new anticonvulsant was compared in efficacy and elavil with amitriptyline which is a classic agent in neuropathic pain treatment.
Read More I have been using Cymbalta for alomost four years, I am very concerned that compare Doc wants to start me on 40mg of Prozac when I have been on mg of Cymbalta. You don't feel high or anything when you take it.
So you start with a dose you can tolerate and work up.
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Its analgesic mechanism has not been fully explained yet; however, it has been demonstrated to have greater effectiveness in providing relief for patients with fibromyalgia than selective serotonin reuptake inhibitors, independent of its antidepressant effects. It has been proposed that the inhibition of noradrenaline reuptake, N-Methyl-D-aspartic acid receptor antagonism, and the blockade of muscarinic receptors and ion channels may contribute to the analgesic effect of amitriptyline [ 12 — 14 ].
It has been demonstrated in various studies that pregabalin is effective in the treatment of fibromyalgia [ 15 — 17 ]. In , it was the first medicine approved by the US Food and Drug Administration for fibromyalgia treatment. It exerts its effect by binding to alpha-2 delta subunits of voltage-sensitive calcium channels and slowing the entry of calcium into neurons It does not interact with benzodiazepine or gamma-aminobutyric acid GABA -A and GABA-B receptors.
Since it does not bind to these receptor sites, it also does not interact with other antiepileptics, antidepressants, or analgesics, and it can be used safely in drug combinations [ 16 ]. The aim of this study was to compare the effectiveness of amitriptyline, with established efficacy in patients with fibromyalgia, with that of pregabalin, the use of which in the treatment of fibromyalgia has become increasingly prevalent in recent years.
Written, informed consent was obtained from all participants. Patients who had previously been operated on for lumbar herniated disc, those who had recently received physical therapy, or pregabalin or antidepressant treatment within the previous 2 months, patients with inflammatory or malignant diseases, pregnant patients, cases with severe psychological disorders or systemic disease were not enrolled in the study.
All participants underwent systemic examination and laboratory assessment of complete blood count, routine biochemical analysis, erythrocyte sedimentation rate, rheumatoid factor, C-reactive protein level, presence of Brucella, and thyroid function was performed. The patients were randomly divided into 2 groups. The patients were evaluated monthly over the course of 3-month treatment for effects using the Visual Analogue Scale VAS for pain, assessment of sleep quality, and side effects of the treatment.
At baseline and at the conclusion of 12 weeks, clinical evaluations were performed in both groups using several measurement tools.
VAS and sleep quality evaluations were performed at 4-week intervals. Pressure pain threshold PPT measurements were taken from tender points 18 points , and control points 3 points: midpoint of the forehead; distal one-third dorsal aspect of the dominant forearm, and nail of the thumb of the dominant hand before and after the treatment using a manual algometry device Force Dial model FDK 40 Push Pull Force Gage; Wagner Instruments, Riverside, CT, USA. Pressure was applied with 1 kg increase per second.
The FIQ was administered to measure the health status of the patients. This disease-specific measure of global health status has been validated for a Turkish population with FMS [ 18 ]. The FIQ is a item, self-administered test that measures physical function, work status, depression, anxiety, sleep, pain, stiffness, fatigue, and well-being.
As score approaches maximum total of it indicates more severe symptoms and disability. The FSS is the most frequently used questionnaire to evaluate the effect of fatigue on daily activities.
Validation and reliability studies for Turkish version were performed by Armutlu et al. The FSS score is the average value of score for all 9 statements. A higher score reflects a more severe state of fatigue [ 19 , 20 ]. The HADS is a self-assessment scale used to determine risks for, level of, and changes in severity of anxiety and depression. Helpful - 0 Tuckamore Hi Again, I just wanted to ad that you may want to post your questions as a new question instead of adding this on to an old post.
You should get better responses if you do that. Weekends tend to be a bit slow in activity. Again thank you for your question. Take care and feel free to contact me for any specific questions. I am very sorry that your husband is having pain. I think it is often just as tough on those that love us when we are suffering. He is lucky to have your caring, concern and compassion. I too have a very injured psoas muscle, ligament and tendon. Mine was injured in a MVA when it all was severed in the groin area some years ago.
It has effected my back stability and causes me great pain, back pain, hip pain and my SI Joint eventually became effected and I have severe pain there. My lower body no longer works as a unit the way it was intended to work. I have copied the following that explains the psoas muscle: Begin Quote: "The psoas muscle is a major muscle in the human body, responsible for stabilizing the base of the spine, allowing the spine to flex, and rotating the hips for a free range of movement.
When kept limber, the psoas functions smoothly with the other muscles of the body to support an upright posture and a flexible lower spine and hips. When the psoas is strained or contracted, it can lead to limitations in free range of motion and an increase of lower back pain. The start of the psoas muscle is found in the lumbar, or lower spine, where the paired psoas muscles anchor on either side of the spine.
The muscles wrap around, into the pelvic area, and attach at the knobby part of the hip with several strong tendons. The psoas muscles are considered to be crucial among the hip flexor muscles.