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The Food and Drug Administration FDA has approved furosemide to treat conditions with volume overload and edema secondary to congestive heart failure exacerbation, liver failure, or renal failure, including the nephrotic syndrome. However, clinicians must be aware of updates related to the indications and administration of furosemide to ensure safe practices and minimize adverse effects.

This activity reviews updates on the recommended use of furosemide, the mechanism of action, indications, contraindications, adverse effects, toxicity, and other key factors e.

It highlights the interprofessional team's role in caring for patients on furosemide therapy. Objectives: Identify the mechanism of action of furosemide. Describe the contraindications to the use of furosemide. Outline the monitoring necessary for patients on furosemide.

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For patients with acutely decompensated heart failure ADHF with volume overload who have not received diuretics previously, the initial dose of furosemide should be 20 to 40 mg intravenously. Later, titrate the furosemide dose according to the clinical response of the patients. However, for those patients with ADHF with a normal kidney function on chronic diuretic therapy, the initial dose of furosemide can be equivalent to or greater than the total oral maintenance dose of furosemide the patient takes daily.

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